A Harvard psychiatrist's practical guide to tapering and discontinuing antidepressants. Written before pharmacogenomics was widely accessible but remains the most practical clinical reference for medication discontinuation — relevant alongside CYP2D6 and SLC6A4 research.
Glenmullen (a Harvard clinical psychiatrist) provides a practical, step-by-step protocol for tapering SSRIs and SNRIs — differentiating true relapse from discontinuation syndrome, matching taper speed to half-life, and managing withdrawal side effects. Backed by case series and the FDA adverse-event database.
One of the earliest mainstream books to catalogue SSRI discontinuation syndrome and to give patients a concrete tapering framework — still widely referenced by prescribers.
These peer-reviewed studies connect to the core ideas in this book. Each result has been scored for reliability.
Covers the research on how specific nutrients — omega-3s, B vitamins, fat-soluble vitamins — affect brain and metabolic function. Directly relevant to FADS1 and BCMO1 variant research on nutrient conversion efficiency.
Two researchers present the evidence for micronutrient support — including methylated B vitamins — in mental health. Directly relevant to MTHFR compound het and the connection between folate processing and neurotransmitter synthesis.
Sports psychology meets physiology. Covers the mental architecture of athletic performance — how to train the brain alongside the body. Particularly relevant for COMT ValVal athletes who perform differently under competition pressure versus low-stakes training.